Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Institute of Social and Preventive Medicine and Clinical Trials Unit, Bern University Hospital, Bern, Switzerland. Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. Department of Cardiology, University Hospital Basel, Basel, Switzerland. Department of Cardiology, Medical University of Vienna, Vienna, Austria. Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands. Department of Cardiology, Radboud UMC, Nijmegen, The Netherlands. Department of Cardiology, Geneva University Hospital, Geneva, Switzerland. Department of Cardiology, University Heart Center Zurich, University Hospital Zurich, Zurich, Switzerland. Department of Pharmacology, Bern University Hospital, Bern, Switzerland and Sanofi, Switzerland. Department of Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, Canada. Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. Electronic address: lorenz.raeber@insel.ch.